Population Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults

INTRODUCTION: SPI-62 is a small-molecule 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor exhibiting complicated nonlinear pharmacokinetics (PK) in human. Previously, we developed a target-mediated drug disposition (TMDD) model to characterize the substantial nonlinear PK of SPI-62. OBJECTI...

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Detalles Bibliográficos
Autores principales: Wu, Nan, Katz, David A., An, Guohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449972/
https://www.ncbi.nlm.nih.gov/pubmed/37452998
http://dx.doi.org/10.1007/s40262-023-01278-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449972/
https://www.ncbi.nlm.nih.gov/pubmed/37452998
http://dx.doi.org/10.1007/s40262-023-01278-8

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