Domain acquisition by class I aminoacyl-tRNA synthetase urzymes coordinated the catalytic functions of HVGH and KMSKS motifs

Leucyl-tRNA synthetase (LeuRS) is a Class I aminoacyl-tRNA synthetase (aaRS) that synthesizes leucyl-tRNA(leu) for codon-directed protein synthesis. Two signature sequences, HxGH and KMSKS help stabilize transition-states for amino acid activation and tRNA aminoacylation by all Class I aaRS. Separat...

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Detalles Bibliográficos
Autores principales: Tang, Guo Qing, Elder, Jessica J H, Douglas, Jordan, Carter, Charles W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450160/
https://www.ncbi.nlm.nih.gov/pubmed/37470821
http://dx.doi.org/10.1093/nar/gkad590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450160/
https://www.ncbi.nlm.nih.gov/pubmed/37470821
http://dx.doi.org/10.1093/nar/gkad590

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