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Domain acquisition by class I aminoacyl-tRNA synthetase urzymes coordinated the catalytic functions of HVGH and KMSKS motifs

Leucyl-tRNA synthetase (LeuRS) is a Class I aminoacyl-tRNA synthetase (aaRS) that synthesizes leucyl-tRNA(leu) for codon-directed protein synthesis. Two signature sequences, HxGH and KMSKS help stabilize transition-states for amino acid activation and tRNA aminoacylation by all Class I aaRS. Separat...

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Detalles Bibliográficos
Autores principales:	Tang, Guo Qing, Elder, Jessica J H, Douglas, Jordan, Carter, Charles W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450160/ https://www.ncbi.nlm.nih.gov/pubmed/37470821 http://dx.doi.org/10.1093/nar/gkad590

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