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Evolution of molecular switches for regulation of transgene expression by clinically licensed gluconate

Synthetic biology holds great promise to improve the safety and efficacy of future gene and engineered cell therapies by providing new means of endogenous or exogenous control of the embedded therapeutic programs. Here, we focused on gluconate as a clinically licensed small-molecule inducer and engi...

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Detalles Bibliográficos
Autores principales: Teixeira, Ana Palma, Xue, Shuai, Huang, Jinbo, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450161/
https://www.ncbi.nlm.nih.gov/pubmed/37497781
http://dx.doi.org/10.1093/nar/gkad600