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Long-read-based single sperm genome sequencing for chromosome-wide haplotype phasing of both SNPs and SVs
Although localized haploid phasing can be achieved using long read genome sequencing without parental data, reliable chromosome-scale phasing remains a great challenge. Given that sperm is a natural haploid cell, single-sperm genome sequencing can provide a chromosome-wide phase signal. Due to the l...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450174/ https://www.ncbi.nlm.nih.gov/pubmed/37351613 http://dx.doi.org/10.1093/nar/gkad532 |