CasDinG is a 5′-3′ dsDNA and RNA/DNA helicase with three accessory domains essential for type IV CRISPR immunity

CRISPR-associated DinG protein (CasDinG) is essential to type IV-A CRISPR function. Here, we demonstrate that CasDinG from Pseudomonas aeruginosa strain 83 is an ATP-dependent 5′-3′ DNA translocase that unwinds double-stranded (ds)DNA and RNA/DNA hybrids. The crystal structure of CasDinG reveals a s...

Descripción completa

Detalles Bibliográficos
Autores principales: Domgaard, Hannah, Cahoon, Christian, Armbrust, Matthew J, Redman, Olivine, Jolley, Alivia, Thomas, Aaron, Jackson, Ryan N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450177/
https://www.ncbi.nlm.nih.gov/pubmed/37395408
http://dx.doi.org/10.1093/nar/gkad546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450177/
https://www.ncbi.nlm.nih.gov/pubmed/37395408
http://dx.doi.org/10.1093/nar/gkad546

Ejemplares similares