Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′- methylguanidine-bridged nucleic acids

Antisense oligonucleotides (ASOs) are becoming a promising class of drugs for treating various diseases. Over the past few decades, many modified nucleic acids have been developed for application to ASOs, aiming to enhance their duplex-forming ability toward cognate mRNA and improve their stability...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Takao, Horie, Naohiro, Aoyama, Hiroshi, Kumagai, Shinji, Obika, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450189/
https://www.ncbi.nlm.nih.gov/pubmed/37462081
http://dx.doi.org/10.1093/nar/gkad608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450189/
https://www.ncbi.nlm.nih.gov/pubmed/37462081
http://dx.doi.org/10.1093/nar/gkad608

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