Combining TSS-MPRA and sensitive TSS profile dissimilarity scoring to study the sequence determinants of transcription initiation

Cis-regulatory elements (CREs) can be classified by the shapes of their transcription start site (TSS) profiles, which are indicative of distinct regulatory mechanisms. Massively parallel reporter assays (MPRAs) are increasingly being used to study CRE regulatory mechanisms, yet the degree to which...

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Detalles Bibliográficos
Autores principales: Guzman, Carlos, Duttke, Sascha, Zhu, Yixin, De Arruda Saldanha, Camila, Downes, Nicholas L, Benner, Christopher, Heinz, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450201/
https://www.ncbi.nlm.nih.gov/pubmed/37403796
http://dx.doi.org/10.1093/nar/gkad562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450201/
https://www.ncbi.nlm.nih.gov/pubmed/37403796
http://dx.doi.org/10.1093/nar/gkad562

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