CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny

Aging is associated with an abnormal increase in DNA methylation (DNAm) in human gene promoters, including in bone marrow stem cells. DNAm patterns are further perturbed in hematological malignancies such as acute myeloid leukemia but the physiological significance of such epigenetic changes is unkn...

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Detalles Bibliográficos
Autores principales: Saunderson, Emily A., Encabo, Hector Huerga, Devis, Julie, Rouault-Pierre, Kevin, Piganeau, Marion, Bell, Christopher G., Gribben, John G., Bonnet, Dominique, Ficz, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450654/
https://www.ncbi.nlm.nih.gov/pubmed/37579157
http://dx.doi.org/10.1073/pnas.2300224120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450654/
https://www.ncbi.nlm.nih.gov/pubmed/37579157
http://dx.doi.org/10.1073/pnas.2300224120

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