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CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny
Aging is associated with an abnormal increase in DNA methylation (DNAm) in human gene promoters, including in bone marrow stem cells. DNAm patterns are further perturbed in hematological malignancies such as acute myeloid leukemia but the physiological significance of such epigenetic changes is unkn...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450654/ https://www.ncbi.nlm.nih.gov/pubmed/37579157 http://dx.doi.org/10.1073/pnas.2300224120 |