Probing Ion Configurations in the KcsA Selectivity Filter with Single-Isotope Labels and 2D IR Spectroscopy

[Image: see text] The potassium ion (K(+)) configurations of the selectivity filter of the KcsA ion channel protein are investigated with two-dimensional infrared (2D IR) spectroscopy of amide I vibrations. Single (13)C–(18)O isotope labels are used, for the first time, to selectively probe the S1/S...

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Detalles Bibliográficos
Autores principales: Ryan, Matthew J., Gao, Lujia, Valiyaveetil, Francis I., Zanni, Martin T., Kananenka, Alexei A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450685/
https://www.ncbi.nlm.nih.gov/pubmed/37578394
http://dx.doi.org/10.1021/jacs.3c05339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450685/
https://www.ncbi.nlm.nih.gov/pubmed/37578394
http://dx.doi.org/10.1021/jacs.3c05339

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