Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic β-cell insulin secretion is excessive and results in hypoglycemia that, without treatment, can cause brain damage or death. Most patients with loss-of-function mutations in ABCC8 and KCNJ11, the genes encoding the β-cell ATP-s...

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Detalles Bibliográficos
Autores principales: Peterson, Sean M., Juliana, Christine A., Hu, Cameron F., Chai, Jinghua, Holliday, Carson, Chan, Kara Y., Lujan Hernandez, Ana G., Challocombe, Zoe, Wang, Linya, Han, Zhen, Haas, Nikhil, Stafford, Ryan, Axelrod, Fumiko, Yuan, Tom Z., De León, Diva D., Sato, Aaron K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2023
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450825/
https://www.ncbi.nlm.nih.gov/pubmed/37358194
http://dx.doi.org/10.2337/db22-1039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450825/
https://www.ncbi.nlm.nih.gov/pubmed/37358194
http://dx.doi.org/10.2337/db22-1039

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