A Route to Potent, Selective, and Biased Salvinorin Chemical Space

[Image: see text] The salvinorins serve as templates for next generation analgesics, antipruritics, and dissociative hallucinogens via selective and potent agonism of the kappa-opioid receptor (KOR). In contrast to most opioids, the salvinorins lack basic amines and bind with high affinity and selec...

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Detalles Bibliográficos
Autores principales: Hill, Sarah J., Dao, Nathan, Dang, Vuong Q., Stahl, Edward L., Bohn, Laura M., Shenvi, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450872/
https://www.ncbi.nlm.nih.gov/pubmed/37637743
http://dx.doi.org/10.1021/acscentsci.3c00616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450872/
https://www.ncbi.nlm.nih.gov/pubmed/37637743
http://dx.doi.org/10.1021/acscentsci.3c00616

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