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A Route to Potent, Selective, and Biased Salvinorin Chemical Space
[Image: see text] The salvinorins serve as templates for next generation analgesics, antipruritics, and dissociative hallucinogens via selective and potent agonism of the kappa-opioid receptor (KOR). In contrast to most opioids, the salvinorins lack basic amines and bind with high affinity and selec...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450872/ https://www.ncbi.nlm.nih.gov/pubmed/37637743 http://dx.doi.org/10.1021/acscentsci.3c00616 |