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Biocompatible Lysine Protecting Groups for the Chemoenzymatic Synthesis of K48/K63 Heterotypic and Branched Ubiquitin Chains

[Image: see text] The elucidation of emerging biological functions of heterotypic and branched ubiquitin (Ub) chains requires new strategies for their preparation with defined lengths and connectivity. While in vitro enzymatic assembly using expressed E1-activating and E2-conjugating enzymes can del...

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Detalles Bibliográficos
Autores principales: Mikami, Toshiki, Majima, Sohei, Song, Haewon, Bode, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450881/
https://www.ncbi.nlm.nih.gov/pubmed/37637747
http://dx.doi.org/10.1021/acscentsci.3c00389