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“Outside-to-inside,” “inside-to-outside,” and “intrinsic” endogenous pathogenic mechanisms in atopic dermatitis: keratinocytes as the key functional cells involved in both permeability barrier dysfunction and immunological alterations

Permeability barrier disruption has been shown to induce immunological alterations (i.e., an “outside-to-inside” pathogenic mechanism). Conversely, several inflammatory and immunological mechanisms reportedly interrupt permeability barrier homeostasis (i.e., an “inside-to-outside” pathogenic mechani...

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Detalles Bibliográficos
Autores principales: Hatano, Yutaka, Elias, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451066/
https://www.ncbi.nlm.nih.gov/pubmed/37638035
http://dx.doi.org/10.3389/fimmu.2023.1239251