Carvedilol Phenocopies PGC-1α Overexpression to Alleviate Oxidative Stress, Mitochondrial Dysfunction and Prevent Doxorubicin-Induced Toxicity in Human iPSC-Derived Cardiomyocytes

Doxorubicin (DOX), one of the most effective and widely used anticancer drugs, has the major limitation of cancer treatment-related cardiotoxicity (CTRTOX) in the clinic. Reactive oxygen species (ROS) generation and mitochondrial dysfunction are well-known consequences of DOX-induced injury to cardi...

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Detalles Bibliográficos
Autores principales: Uche, Nnamdi, Dai, Qiang, Lai, Shuping, Kolander, Kurt, Thao, Mai, Schibly, Elizabeth, Sendaydiego, Xavier, Zielonka, Jacek, Benjamin, Ivor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451268/
https://www.ncbi.nlm.nih.gov/pubmed/37627583
http://dx.doi.org/10.3390/antiox12081585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451268/
https://www.ncbi.nlm.nih.gov/pubmed/37627583
http://dx.doi.org/10.3390/antiox12081585

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