AMPK-Mediated Phosphorylation of Nrf2 at S374/S408/S433 Favors Its βTrCP2-Mediated Degradation in KEAP1-Deficient Cells

Nrf2 is a transcription factor facilitating cells’ resilience against redox and various other forms of stress. In the absence of stressors, KEAP1 and/or βTrCP mediate the ubiquitination of Nrf2 and prevent Nrf2-dependent gene expression and detoxification. AMPK regulates cellular energy homeostasis...

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Detalles Bibliográficos
Autores principales: Petsouki, Eleni, Ender, Sylvia, Sosa Cabrera, Shara Natalia, Heiss, Elke H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451539/
https://www.ncbi.nlm.nih.gov/pubmed/37627580
http://dx.doi.org/10.3390/antiox12081586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451539/
https://www.ncbi.nlm.nih.gov/pubmed/37627580
http://dx.doi.org/10.3390/antiox12081586

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