A New Quinone-Based Inhibitor of Mitochondrial Complex I in D-Conformation, Producing Invasion Reduction and Sensitization to Venetoclax in Breast Cancer Cells

Mitochondrial Complex I plays a crucial role in the proliferation, chemoresistance, and metastasis of breast cancer (BC) cells. This highlights it as an attractive target for anti-cancer drugs. Using submitochondrial particles, we identified FRV–1, an ortho-carbonyl quinone, which inhibits NADH:duro...

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Detalles Bibliográficos
Autores principales: Monroy-Cárdenas, Matías, Andrades, Víctor, Almarza, Cristopher, Vera, María Jesús, Martínez, Jorge, Pulgar, Rodrigo, Amalraj, John, Araya-Maturana, Ramiro, Urra, Félix A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451541/
https://www.ncbi.nlm.nih.gov/pubmed/37627592
http://dx.doi.org/10.3390/antiox12081597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451541/
https://www.ncbi.nlm.nih.gov/pubmed/37627592
http://dx.doi.org/10.3390/antiox12081597

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