Functional and Structural Insights into the Human PPARα/δ/γ Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor

No therapeutic drugs are currently available for nonalcoholic steatohepatitis (NASH) that progresses from nonalcoholic fatty liver via oxidative stress-involved pathways. Three cognate peroxisome proliferator-activated receptor (PPAR) subtypes (PPARα/δ/γ) are considered as attractive targets. Althou...

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Detalles Bibliográficos
Autores principales: Kamata, Shotaro, Honda, Akihiro, Ishikawa, Ryo, Akahane, Makoto, Fujita, Ayane, Kaneko, Chihiro, Miyawaki, Saeka, Habu, Yuki, Shiiyama, Yui, Uchii, Kie, Machida, Yui, Oyama, Takuji, Ishii, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451623/
https://www.ncbi.nlm.nih.gov/pubmed/37627519
http://dx.doi.org/10.3390/antiox12081523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451623/
https://www.ncbi.nlm.nih.gov/pubmed/37627519
http://dx.doi.org/10.3390/antiox12081523

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