Combination Therapy with Ciprofloxacin and Pentamidine against Multidrug-Resistant Pseudomonas aeruginosa: Assessment of In Vitro and In Vivo Efficacy and the Role of Resistance–Nodulation–Division (RND) Efflux Pumps

The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P. aeruginosa and (ii) determine if pentamidine acts as an efflux-pump inhibitor. Resistant clinical isolates, mutant s...

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Detalles Bibliográficos
Autores principales: Fletcher, Megan, McCormack, Alex, Parcell, Benjamin J., Coote, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451767/
https://www.ncbi.nlm.nih.gov/pubmed/37627656
http://dx.doi.org/10.3390/antibiotics12081236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451767/
https://www.ncbi.nlm.nih.gov/pubmed/37627656
http://dx.doi.org/10.3390/antibiotics12081236

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