Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs

Background: Low back pain is a global health problem directly related to intervertebral disc (IVD) degeneration. Senolytic drugs (RG-7112 and o-Vanillin) target and remove senescent cells from IVDs in vitro, improving tissue homeostasis. One drawback of using a single senolytic agent is the failure...

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Detalles Bibliográficos
Autores principales: Mannarino, Matthew, Wu-Martinez, Oliver, Sheng, Kai, Li, Li, Navarro-Ramirez, Rodrigo, Jarzem, Peter, Ouellet, Jean A., Cherif, Hosni, Haglund, Lisbet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452201/
https://www.ncbi.nlm.nih.gov/pubmed/37627322
http://dx.doi.org/10.3390/biom13081257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452201/
https://www.ncbi.nlm.nih.gov/pubmed/37627322
http://dx.doi.org/10.3390/biom13081257

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