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In Silico Simulations Reveal Molecular Mechanism of Uranyl Ion Toxicity towards DNA-Binding Domain of PARP-1 Protein

The molecular toxicity of the uranyl ion (UO(2)(2+)) in living cells is primarily determined by its high affinity to both native and potential metal-binding sites that commonly occur in the structure of biomolecules. Recent advances in computational and experimental research have shed light on the s...

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Detalles Bibliográficos
Autores principales: Bulavko, Egor S., Pak, Marina A., Ivankov, Dmitry N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452222/
https://www.ncbi.nlm.nih.gov/pubmed/37627334
http://dx.doi.org/10.3390/biom13081269