Adenosine A(2A) Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ(1–42) to Model Early Alzheimer’s Disease

The intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer’s disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of hippocampal long-term potentiation (LTP) that are prevented by the blockade of adenosine A(2A) receptors (A(2A)R). Since...

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Detalles Bibliográficos
Autores principales: Lopes, Cátia R., Silva, António C., Silva, Henrique B., Canas, Paula M., Agostinho, Paula, Cunha, Rodrigo A., Lopes, João Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452250/
https://www.ncbi.nlm.nih.gov/pubmed/37627238
http://dx.doi.org/10.3390/biom13081173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452250/
https://www.ncbi.nlm.nih.gov/pubmed/37627238
http://dx.doi.org/10.3390/biom13081173

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