BRCA1 and NORE1A Form a Her2/Ras Regulated Tumor Suppressor Complex Modulating Senescence

SIMPLE SUMMARY: The loss of function of the BRCA1 tumor suppressor is common in breast cancer, but experimentally, the BRCA1 inactivation promotes cell senescence. The overstimulation of RAS signaling via Her2 upregulation is also common in breast cancer, yet it can also lead to senescence. A signif...

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Detalles Bibliográficos
Autores principales: Nelson, Nicholas, Jigo, Raphael, Clark, Geoffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452424/
https://www.ncbi.nlm.nih.gov/pubmed/37627161
http://dx.doi.org/10.3390/cancers15164133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452424/
https://www.ncbi.nlm.nih.gov/pubmed/37627161
http://dx.doi.org/10.3390/cancers15164133

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