Methadone Maintenance and QT-Interval: Prevalence and Risk Factors—Is It Effective to Switch Therapy to Levomethadone?

Methadone is a chiral synthetic opioid primarily used to treat heroin and prescription-opioid addiction: the (R)-enantiomer (Levomethadone) activates the µ-opioid receptor more potently than the (S)-enantiomer, which is a more potent blocker of the hERG potassium channels, resulting in QTc prolongat...

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Detalles Bibliográficos
Autores principales: Santin, Laura, Verlato, Giuseppe, Tfaily, Ahmad, Manera, Roberto, Zinfollino, Giuseppe, Fusina, Francesca, Lugoboni, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452549/
https://www.ncbi.nlm.nih.gov/pubmed/37626606
http://dx.doi.org/10.3390/biomedicines11082109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452549/
https://www.ncbi.nlm.nih.gov/pubmed/37626606
http://dx.doi.org/10.3390/biomedicines11082109

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