Variant Characterization of a Representative Large Pedigree Suggests “Variant Risk Clusters” Convey Varying Predisposition of Risk to Lynch Syndrome

SIMPLE SUMMARY: Approximately 20% of colorectal cancer (CRC) cases are diagnosed in individuals under 40, with a severe prognosis due to germline variant accumulation. Many of these variants have been classified as hereditary cancer causative, while others remain poorly researched. The identificatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Barbirou, Mouadh, Miller, Amanda A., Mezlini, Amel, Bouhaouala-Zahar, Balkiss, Tonellato, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452890/
https://www.ncbi.nlm.nih.gov/pubmed/37627102
http://dx.doi.org/10.3390/cancers15164074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452890/
https://www.ncbi.nlm.nih.gov/pubmed/37627102
http://dx.doi.org/10.3390/cancers15164074

Ejemplares similares