Cargando…

Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells

Patients with advanced prostate cancer (PCa) invariably develop resistance to anti-androgen therapy and taxane-based chemotherapy. Glucocorticoid receptor (GR) has been implicated in PCa therapy resistance; however, the mechanisms underlying GR-mediated chemoresistance remain unclear. Lens epitheliu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sanchez-Hernandez, Evelyn S., Ochoa, Pedro T., Suzuki, Tise, Ortiz-Hernandez, Greisha L., Unternaehrer, Juli J., Alkashgari, Hossam R., Diaz Osterman, Carlos J., Martinez, Shannalee R., Chen, Zhong, Kremsky, Isaac, Wang, Charles, Casiano, Carlos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453226/ https://www.ncbi.nlm.nih.gov/pubmed/37626856 http://dx.doi.org/10.3390/cells12162046

Ejemplares similares

The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells
por: Ortiz-Hernandez, Greisha L., et al.
Publicado: (2021)

Glucocorticoid Receptor and β-Catenin Interact in Prostate Cancer Cells and Their Co-Inhibition Attenuates Tumorsphere Formation, Stemness, and Docetaxel Resistance
por: Martinez, Shannalee R., et al.
Publicado: (2023)

Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions
por: Ortiz-Hernandez, Greisha L., et al.
Publicado: (2020)

Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75
por: Mediavilla-Varela, Melanie, et al.
Publicado: (2009)

The Nuclear Dense Fine Speckled (DFS) Immunofluorescence Pattern: Not All Roads Lead to DFS70/LEDGFp75
por: Sanchez-Hernandez, Evelyn S., et al.
Publicado: (2023)

LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer
por: Basu, Anamika, et al.
Publicado: (2016)

Glucocorticoids Induce Stress Oncoproteins Associated with Therapy-Resistance in African American and European American Prostate Cancer Cells
por: Woods-Burnham, Leanne, et al.
Publicado: (2018)

Analysis of LEDGF/p75 expression regulation
por: Desfarges, Sébastien, et al.
Publicado: (2009)

Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes
por: Ríos-Colón, Leslimar, et al.
Publicado: (2017)

Expression of the Stress Response Oncoprotein LEDGF/p75 in Human Cancer: A Study of 21 Tumor Types
por: Basu, Anamika, et al.
Publicado: (2012)

RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance
por: Cajigas-Du Ross, Christina K., et al.
Publicado: (2018)

The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75
por: Zhang, Da-Wei, et al.
Publicado: (2020)

LEDGF/p75 Is Required for an Efficient DNA Damage Response
por: Liedtke, Victoria, et al.
Publicado: (2021)

Alpha-Enolase: Emerging Tumor-Associated Antigen, Cancer Biomarker, and Oncotherapeutic Target
por: Almaguel, Frankis A., et al.
Publicado: (2021)

TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia
por: Alkashgari, Hossam R., et al.
Publicado: (2022)

LEDGF/p75 is critical but not essential for multiple-round HIV 1 replication
por: Schrijvers, RLG, et al.
Publicado: (2010)

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
por: Desimmie, Belete Ayele, et al.
Publicado: (2015)

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication
por: Engelman, Alan, et al.
Publicado: (2008)

Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting
por: Marshall, Heather M., et al.
Publicado: (2007)

High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region
por: De Rijck, Jan, et al.
Publicado: (2010)

Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
por: Desimmie, Belete Ayele, et al.
Publicado: (2020)

PB1704: LEDGF/P75 ASSOCIATED WITH CHEMORESISTANCE IN MIXED-LINEAGE LEUKEMIA
por: Akele, Muluembet, et al.
Publicado: (2023)

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor
por: Wang, Hao, et al.
Publicado: (2012)

Role of epithelial-mesenchymal transition factor SNAI1 and its targets in ovarian cancer aggressiveness
por: Suzuki, Tise, et al.
Publicado: (2023)

Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV
por: Hombrouck, Anneleen, et al.
Publicado: (2007)

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
por: Cherepanov, Peter
Publicado: (2007)

LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors
por: Meehan, Anne M., et al.
Publicado: (2009)

LEDGF/p75 IN interaction inhibitors: in silico studies of an old target with novel approach
por: Pant, Amit M, et al.
Publicado: (2014)

Characterization of LEDGF/p75 Genetic Variants and Association with HIV-1 Disease Progression
por: Messiaen, Peter, et al.
Publicado: (2012)

LEDGF/p75 Deficiency Increases Deletions at the HIV-1 cDNA Ends
por: Bueno, Murilo T. D., et al.
Publicado: (2017)

Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75
por: Lapaillerie, Delphine, et al.
Publicado: (2021)

HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin
por: Astiazaran, Paulina, et al.
Publicado: (2011)

THU502 CYR61, A Member Of The CCN Protein Family, Regulates IGF1 In Metastatic Prostate Cancer
por: Ortiz Hernandez, Greisha L, et al.
Publicado: (2023)

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75
por: Kessl, Jacques J., et al.
Publicado: (2011)

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity
por: Tocco, Graziella, et al.
Publicado: (2023)

Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain
por: Tsutsui, Kimiko M., et al.
Publicado: (2011)

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells
por: Schrijvers, Rik, et al.
Publicado: (2012)

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV
por: Vranckx, Lenard S., et al.
Publicado: (2016)

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes
por: Singh, Parmit Kumar, et al.
Publicado: (2015)

Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins
por: Pradeepa, Madapura M., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5fba4ansrak447i1j43jrmn08v