Forced Swimming-Induced Depressive-like Behavior and Anxiety Are Reduced by Chlorpheniramine via Suppression of Oxidative and Inflammatory Mediators and Activating the Nrf2-BDNF Signaling Pathway

The first-generation antihistamine chlorpheniramine (CPA) is believed to have both anxiolytic and antidepressant properties. The current study sought to assess the mechanisms behind the antidepressant and anxiolytic effects of CPA therapy concerning oxidative stress, inflammation, and nuclear factor...

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Detalles Bibliográficos
Autores principales: Alamri, Hasan S., Mufti, Rana, Sabir, Deema Kamal, Abuderman, Abdulwahab A., Dawood, Amal F., ShamsEldeen, Asmaa M., Haidara, Mohamed A., Isenovic, Esma R., El-Bidawy, Mahmoud H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453464/
https://www.ncbi.nlm.nih.gov/pubmed/37623226
http://dx.doi.org/10.3390/cimb45080407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453464/
https://www.ncbi.nlm.nih.gov/pubmed/37623226
http://dx.doi.org/10.3390/cimb45080407

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