GastroPlus- and HSPiP-Oriented Predictive Parameters as the Basis of Valproic Acid-Loaded Mucoadhesive Cationic Nanoemulsion Gel for Improved Nose-to-Brain Delivery to Control Convulsion in Humans

Oral and parenteral delivery routes of valproic acid (VA) are associated with serious adverse effects, high hepatic metabolism, high clearance, and low bioavailability in the brain. A GastroPlus program was used to predict in vivo performance of immediate (IR) and sustained release (SR) products in...

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Detalles Bibliográficos
Autores principales: Hussain, Afzal, Altamimi, Mohammad A., Ramzan, Mohhammad, Mirza, Mohd Aamir, Khuroo, Tahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453491/
https://www.ncbi.nlm.nih.gov/pubmed/37623058
http://dx.doi.org/10.3390/gels9080603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453491/
https://www.ncbi.nlm.nih.gov/pubmed/37623058
http://dx.doi.org/10.3390/gels9080603

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