Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development

Poly(ADP-ribose) polymerase-1 (PARP1) binds DNA lesions to catalyse poly(ADP-ribosyl)ation (PARylation) using NAD+ as a substrate. PARP1 plays multiple roles in cellular activities, including DNA repair, transcription, cell death, and chromatin remodelling. However, whether these functions are gover...

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Detalles Bibliográficos
Autores principales: Kamaletdinova, Tatiana, Zong, Wen, Urbánek, Pavel, Wang, Sijia, Sannai, Mara, Grigaravičius, Paulius, Sun, Wenli, Fanaei-Kahrani, Zahra, Mangerich, Aswin, Hottiger, Michael O., Li, Tangliang, Wang, Zhao-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453916/
https://www.ncbi.nlm.nih.gov/pubmed/37626888
http://dx.doi.org/10.3390/cells12162078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453916/
https://www.ncbi.nlm.nih.gov/pubmed/37626888
http://dx.doi.org/10.3390/cells12162078

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