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A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity

The n-3 polyunsaturated fatty acids (PUFAs) can reduce inflammatory markers and may therefore be useful in obesity management. The aim of this study was to analyze the effect of supplementation with n-3 PUFAs on total fatty acid profile in red blood cells (RBCs), as well as biochemical and inflammat...

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Autores principales: Gonzalez-Becerra, Karina, Barron-Cabrera, Elisa, Muñoz-Valle, Jose F., Torres-Castillo, Nathaly, Rivera-Valdes, Juan J., Rodriguez-Echevarria, Roberto, Martinez-Lopez, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454033/
https://www.ncbi.nlm.nih.gov/pubmed/37628530
http://dx.doi.org/10.3390/healthcare11162333
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author Gonzalez-Becerra, Karina
Barron-Cabrera, Elisa
Muñoz-Valle, Jose F.
Torres-Castillo, Nathaly
Rivera-Valdes, Juan J.
Rodriguez-Echevarria, Roberto
Martinez-Lopez, Erika
author_facet Gonzalez-Becerra, Karina
Barron-Cabrera, Elisa
Muñoz-Valle, Jose F.
Torres-Castillo, Nathaly
Rivera-Valdes, Juan J.
Rodriguez-Echevarria, Roberto
Martinez-Lopez, Erika
author_sort Gonzalez-Becerra, Karina
collection PubMed
description The n-3 polyunsaturated fatty acids (PUFAs) can reduce inflammatory markers and may therefore be useful in obesity management. The aim of this study was to analyze the effect of supplementation with n-3 PUFAs on total fatty acid profile in red blood cells (RBCs), as well as biochemical and inflammatory markers, in subjects with obesity. The study consisted in a randomized placebo-controlled, double-blind clinical trial involving 41 subjects with obesity during a 4-month follow-up. Individuals were randomly assigned to two groups: n-3 PUFA supplementation (1.5 g fish oil) and placebo (1.5 g sunflower oil). Anthropometric, biochemical, dietetic, cytokine and total fatty acid profiles in RBCs were measured. Both groups increased their PUFA intake and DHA incorporation in RBCs. However, the placebo group showed a reduction in serum IL-8 and MCP-1 at the end of the study. A multiple linear regression model adjusted by body fat mass and sex showed that an increase in DHA in RBCs decreased the serum IL-8 levels in both study groups at the end of the study. Our results highlight the role of dietary DHA and n-3 supplementation usefulness in exerting beneficial anti-inflammatory effects.
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spelling pubmed-104540332023-08-26 A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity Gonzalez-Becerra, Karina Barron-Cabrera, Elisa Muñoz-Valle, Jose F. Torres-Castillo, Nathaly Rivera-Valdes, Juan J. Rodriguez-Echevarria, Roberto Martinez-Lopez, Erika Healthcare (Basel) Article The n-3 polyunsaturated fatty acids (PUFAs) can reduce inflammatory markers and may therefore be useful in obesity management. The aim of this study was to analyze the effect of supplementation with n-3 PUFAs on total fatty acid profile in red blood cells (RBCs), as well as biochemical and inflammatory markers, in subjects with obesity. The study consisted in a randomized placebo-controlled, double-blind clinical trial involving 41 subjects with obesity during a 4-month follow-up. Individuals were randomly assigned to two groups: n-3 PUFA supplementation (1.5 g fish oil) and placebo (1.5 g sunflower oil). Anthropometric, biochemical, dietetic, cytokine and total fatty acid profiles in RBCs were measured. Both groups increased their PUFA intake and DHA incorporation in RBCs. However, the placebo group showed a reduction in serum IL-8 and MCP-1 at the end of the study. A multiple linear regression model adjusted by body fat mass and sex showed that an increase in DHA in RBCs decreased the serum IL-8 levels in both study groups at the end of the study. Our results highlight the role of dietary DHA and n-3 supplementation usefulness in exerting beneficial anti-inflammatory effects. MDPI 2023-08-18 /pmc/articles/PMC10454033/ /pubmed/37628530 http://dx.doi.org/10.3390/healthcare11162333 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gonzalez-Becerra, Karina
Barron-Cabrera, Elisa
Muñoz-Valle, Jose F.
Torres-Castillo, Nathaly
Rivera-Valdes, Juan J.
Rodriguez-Echevarria, Roberto
Martinez-Lopez, Erika
A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity
title A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity
title_full A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity
title_fullStr A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity
title_full_unstemmed A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity
title_short A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity
title_sort balanced dietary ratio of n-6:n-3 polyunsaturated fatty acids exerts an effect on total fatty acid profile in rbcs and inflammatory markers in subjects with obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454033/
https://www.ncbi.nlm.nih.gov/pubmed/37628530
http://dx.doi.org/10.3390/healthcare11162333
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