Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition

Leiomyomas (fibroids) are monoclonal tumors in which myometrial stem cells (MSCs) turn tumorigenic after mutation, abnormal methylation, or aberrant signaling. Several factors contribute to metabolic dysfunction in obesity, including abnormal cellular proliferation, oxidative stress, and DNA damage....

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Detalles Bibliográficos
Autores principales: Afrin, Sadia, Kirschen, Gregory W., Borahay, Mostafa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454202/
https://www.ncbi.nlm.nih.gov/pubmed/37628676
http://dx.doi.org/10.3390/genes14081625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454202/
https://www.ncbi.nlm.nih.gov/pubmed/37628676
http://dx.doi.org/10.3390/genes14081625

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