Insights into the Inhibitory Mechanisms of the Covalent Drugs for DNMT3A

The perturbations of DNA methyltransferase 3 alpha (DNMT3A) may cause uncontrolled gene expression, resulting in cancers and tumors. The DNMT inhibitors Azacytidine (AZA) and Zebularine (ZEB) inhibit the DNMT family with no specificities, and consequently would bring side effects during the treatmen...

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Detalles Bibliográficos
Autores principales: Yang, Wei, Zhuang, Jingyuan, Li, Chen, Bai, Chen, Cheng, Guijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454219/
https://www.ncbi.nlm.nih.gov/pubmed/37628829
http://dx.doi.org/10.3390/ijms241612652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454219/
https://www.ncbi.nlm.nih.gov/pubmed/37628829
http://dx.doi.org/10.3390/ijms241612652

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