Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype

Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. Ubiquitously expressed in humans, TG2 can act either as a transamidase by crosslinking two substrates through formation of an N(ε)(ɣ-glutaminyl)lysine bond or as an intracellular G-protein. These di...

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Detalles Bibliográficos
Autores principales: Gates, Eric W. J., Calvert, Nicholas D., Cundy, Nicholas J., Brugnoli, Federica, Navals, Pauline, Kirby, Alexia, Bianchi, Nicoletta, Adhikary, Gautam, Shuhendler, Adam J., Eckert, Richard L., Keillor, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454375/
https://www.ncbi.nlm.nih.gov/pubmed/37628729
http://dx.doi.org/10.3390/ijms241612546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454375/
https://www.ncbi.nlm.nih.gov/pubmed/37628729
http://dx.doi.org/10.3390/ijms241612546

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