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Epithelial Galectin-3 Induced the Mitochondrial Complex Inhibition and Cell Cycle Arrest of CD8(+) T Cells in Severe/Critical COVID-19

Previous research suggested that the dramatical decrease in CD8(+) T cells is a contributing factor in the poor prognosis and disease progression of COVID-19 patients. However, the underlying mechanisms are not fully understood. In this study, we conducted Single-cell RNA sequencing (scRNA-seq) and...

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Detalles Bibliográficos
Autores principales: Wang, Yudie, Yang, Cheng, Wang, Zhongyi, Wang, Yi, Yan, Qing, Feng, Ying, Liu, Yanping, Huang, Juan, Zhou, Jingjiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454470/
https://www.ncbi.nlm.nih.gov/pubmed/37628961
http://dx.doi.org/10.3390/ijms241612780