SMRT Sequencing Enables High-Throughput Identification of Novel AAVs from Capsid Shuffling and Directed Evolution

The use of AAV capsid libraries coupled with various selection strategies has proven to be a remarkable approach for generating novel AAVs with enhanced and desired features. The inability to reliably sequence the complete capsid gene in a high-throughput manner has been the bottleneck of capsid eng...

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Detalles Bibliográficos
Autores principales: Casy, Widler, Garza, Irvin T., Chen, Xin, Dong, Thomas, Hu, Yuhui, Kanchwala, Mohammed, Trygg, Cynthia B., Shyng, Charles, Xing, Chao, Bunnell, Bruce A., Braun, Stephen E., Gray, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454592/
https://www.ncbi.nlm.nih.gov/pubmed/37628711
http://dx.doi.org/10.3390/genes14081660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454592/
https://www.ncbi.nlm.nih.gov/pubmed/37628711
http://dx.doi.org/10.3390/genes14081660

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