The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice

The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer’s disease (AD), is well-accepted. Therefore, the procognitive effects of acute systemic administration of H3R antagonist E169 (2.5–10...

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Detalles Bibliográficos
Autores principales: Abdalla, Sabna, Eissa, Nermin, Jayaprakash, Petrilla, Beiram, Rami, Kuder, Kamil J., Łażewska, Dorota, Kieć-Kononowicz, Katarzyna, Sadek, Bassem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454630/
https://www.ncbi.nlm.nih.gov/pubmed/37628900
http://dx.doi.org/10.3390/ijms241612719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454630/
https://www.ncbi.nlm.nih.gov/pubmed/37628900
http://dx.doi.org/10.3390/ijms241612719

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