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DREADD activation of the lateral orbitofrontal increases cocaine-taking and cocaine-seeking in male and female rats during intermittent access self-administration under risky conditions

Addiction is a disorder that can be characterized in part as the constant pursuit of a particular substance despite negative consequences. Although the orbitofrontal cortex (OFC) is known to regulate risk-taking more generally and be critical to the development of addiction, its role in regulating d...

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Detalles Bibliográficos
Autores principales: Murphy, Zackari D., Mulugeta, Ruth, Tran, Alex, Ferguson, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455039/
https://www.ncbi.nlm.nih.gov/pubmed/37637005
http://dx.doi.org/10.1016/j.addicn.2023.100122