From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington’s Disease Research

Huntington’s disease (HD) is a debilitating neurodegenerative genetic disorder caused by an expanded polyglutamine-coding (CAG) trinucleotide repeat in the huntingtin (HTT) gene. HD behaves as a highly penetrant dominant disorder likely acting through a toxic gain of function by the mutant huntingti...

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Detalles Bibliográficos
Autores principales: Jiang, Andrew, Handley, Renee R., Lehnert, Klaus, Snell, Russell G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455900/
https://www.ncbi.nlm.nih.gov/pubmed/37629202
http://dx.doi.org/10.3390/ijms241613021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455900/
https://www.ncbi.nlm.nih.gov/pubmed/37629202
http://dx.doi.org/10.3390/ijms241613021

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