Cargando…

From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington’s Disease Research

Huntington’s disease (HD) is a debilitating neurodegenerative genetic disorder caused by an expanded polyglutamine-coding (CAG) trinucleotide repeat in the huntingtin (HTT) gene. HD behaves as a highly penetrant dominant disorder likely acting through a toxic gain of function by the mutant huntingti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Andrew, Handley, Renee R., Lehnert, Klaus, Snell, Russell G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455900/ https://www.ncbi.nlm.nih.gov/pubmed/37629202 http://dx.doi.org/10.3390/ijms241613021

Ejemplares similares

A Multi-Omic Huntington’s Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis
por: Mears, Emily R., et al.
Publicado: (2021)

A Review of the Current Mammalian Models of Alzheimer’s Disease and Challenges That Need to Be Overcome
por: Mckean, Natasha Elizabeth, et al.
Publicado: (2021)

Metabolic disruption identified in the Huntington’s disease transgenic sheep model
por: Handley, Renee. R., et al.
Publicado: (2016)

Multiple pathways contribute to the pathogenesis of Huntington disease
por: Li, Shihua, et al.
Publicado: (2006)

Pathogenesis and potential therapeutic application of stem cells transplantation in Huntington’s disease
por: Saha, Sudeepto, et al.
Publicado: (2022)

Mitochondria in Huntington’s disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies
por: Jurcau, Anamaria, et al.
Publicado: (2022)

Microglial Activation in the Pathogenesis of Huntington’s Disease
por: Yang, Hui-Ming, et al.
Publicado: (2017)

ICARUS, an interactive web server for single cell RNA-seq analysis
por: Jiang, Andrew, et al.
Publicado: (2022)

Delineation of complex gene expression patterns in single cell RNA-seq data with ICARUS v2.0
por: Jiang, Andrew, et al.
Publicado: (2023)

Observing Huntington’s Disease: the European Huntington’s Disease Network’s REGISTRY
por: Orth, Michael, et al.
Publicado: (2011)

Huntington’s Disease Pathogenesis: Two Sequential Components
por: Hong, Eun Pyo, et al.
Publicado: (2021)

Biological Aging and the Cellular Pathogenesis of Huntington’s Disease
por: Machiela, Emily, et al.
Publicado: (2020)

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington’s Disease
por: Rattray, Ivan, et al.
Publicado: (2017)

Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy
por: Chang, Renbao, et al.
Publicado: (2015)

Therapeutic Strategies in Huntington's Disease
por: Kanazawa, Ichiro
Publicado: (2006)

Therapeutic Advances for Huntington’s Disease
por: Kumar, Ashok, et al.
Publicado: (2020)

MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
por: Hoss, Andrew G., et al.
Publicado: (2014)

Molecular Research on Huntington’s Disease
por: Valor, Luis M.
Publicado: (2023)

Gut Bacteria Regulate the Pathogenesis of Huntington’s Disease in Drosophila Model
por: Chongtham, Anjalika, et al.
Publicado: (2022)

Therapeutic Advances in the Management of Huntington’s Disease
por: Abdulrahman, Ganiy Opeyemi
Publicado: (2011)

MicroRNA‐150 serves as a diagnostic biomarker and is involved in the inflammatory pathogenesis of Parkinson's disease
por: Li, Haiting, et al.
Publicado: (2020)

Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington’s disease
por: Landles, Christian, et al.
Publicado: (2012)

150 years of British psychiatry 1841–1991
por: Scull, Andrew
Publicado: (1993)

150 years of dental education and research - University of Birmingham School of Dentistry
por: Patel, Upen, et al.
Publicado: (2022)

Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis
por: Onur, Tarik Seref, et al.
Publicado: (2021)

RBV: Read balance validator, a tool for prioritising copy number variations in germline conditions
por: Whitford, Whitney, et al.
Publicado: (2019)

Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model
por: Jiang, Wenxiao, et al.
Publicado: (2015)

The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
por: Tung, Chih-Wei, et al.
Publicado: (2021)

Pathogenesis of Huntington’s Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies
por: Irfan, Zainab, et al.
Publicado: (2022)

Corrigendum: Gut bacteria regulate the pathogenesis of Huntington's disease in Drosophila model
por: Chongtham, Anjalika, et al.
Publicado: (2022)

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
por: Miguez, Andrés, et al.
Publicado: (2023)

Therapeutic and Mechanistic Effects of Curcumin in Huntington’s Disease
por: Labanca, Fabiana, et al.
Publicado: (2021)

Neuroinflammation in Huntington’s disease: From animal models to clinical therapeutics
por: Jia, Qingqing, et al.
Publicado: (2022)

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review
por: Manoharan, Shanmugam, et al.
Publicado: (2016)

Formation of Polyglutamine Inclusions in a Wide Range of Non-CNS Tissues in the HdhQ150 Knock-In Mouse Model of Huntington's Disease
por: Moffitt, Hilary, et al.
Publicado: (2009)

Absence of Acanthocytosis in Huntington’s Disease-like 2: A Prospective Comparison with Huntington’s Disease
por: Anderson, David G., et al.
Publicado: (2017)

Skeletal Muscle Modulates Huntington’s Disease Pathogenesis in Mice: Role of Physical Exercise
por: Corrochano, Silvia, et al.
Publicado: (2018)

Harleß’ Apparatus of Will: 150 years later
por: Pfister, Roland, et al.
Publicado: (2011)

150 Years of the Mass Action Law
por: Voit, Eberhard O., et al.
Publicado: (2015)

Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease
por: Kim, Sangjune, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vi4nmddemimstlerib93pivq3g