Petrosamine Revisited. Experimental and Computational Investigation of Solvatochromism, Tautomerism and Free Energy Landscapes of a Pyridoacridinium Quaternary Salt

Petrosamine (1)—a colored pyridoacridine alkaloid from the Belizean sponge, Petrosia sp., that is also a potent inhibitor of acetylcholine esterase (AChE)—was investigated by spectroscopic and computational methods. Analysis of the petrosamine-free energy landscapes, pK(a) and tautomerism, revealed...

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Detalles Bibliográficos
Autores principales: Gartshore, Christopher J., Wang, Xiao, Su, Yongxuan, Molinski, Tadeusz F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455967/
https://www.ncbi.nlm.nih.gov/pubmed/37623727
http://dx.doi.org/10.3390/md21080446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455967/
https://www.ncbi.nlm.nih.gov/pubmed/37623727
http://dx.doi.org/10.3390/md21080446

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