Persistent extrasynaptic hyperdopaminergia in the mouse hippocampus induces plasticity and recognition memory deficits reversed by the atypical antipsychotic sulpiride

Evidence suggests that subcortical hyperdopaminergia alters cognitive function in schizophrenia and antipsychotic drugs (APD) fail at rescuing cognitive deficits in patients. In a previous study, we showed that blocking D2 dopamine receptors (D2R), a core action of APD, led to profound reshaping of...

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Detalles Bibliográficos
Autores principales: Rocchetti, Jill, Fasano, Caroline, Dal-Bo, Gregory, Guma, Elisa, El Mestikawy, Salah, Wong, Tak-Pan, Fakhfouri, Gohar, Giros, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456148/
https://www.ncbi.nlm.nih.gov/pubmed/37624765
http://dx.doi.org/10.1371/journal.pone.0289770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456148/
https://www.ncbi.nlm.nih.gov/pubmed/37624765
http://dx.doi.org/10.1371/journal.pone.0289770

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