Cargando…

The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models

Huntington’s disease (HD) is caused by the expansion of a polyglutamine (polyQ)-encoding tract in exon 1 of the huntingtin gene to greater than 35 CAG repeats. It typically has a disease course lasting 15–20 years, and there are currently no disease-modifying therapies available. Thus, there is a ne...

Descripción completa

Detalles Bibliográficos
Autores principales:	Speziale, Roberto, Montesano, Camilla, Di Pietro, Giulia, Cicero, Daniel Oscar, Summa, Vincenzo, Monteagudo, Edith, Orsatti, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456449/ https://www.ncbi.nlm.nih.gov/pubmed/37623904 http://dx.doi.org/10.3390/metabo13080961

Ejemplares similares

Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
por: Adhikari, Mohit H., et al.
Publicado: (2023)

Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020)

Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175(+/−) Mouse Model of Huntington's Disease
por: Lim, Sean Austin O., et al.
Publicado: (2021)

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
por: Sanchis, Ana, et al.
Publicado: (2019)

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
por: Menalled, Liliana B., et al.
Publicado: (2012)

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice
por: Schindler, Franziska, et al.
Publicado: (2021)

Improved synthesis of [(18)F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors
por: Huhtala, Tuulia, et al.
Publicado: (2019)

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2016)

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
por: Heikkinen, Taneli, et al.
Publicado: (2012)

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
por: Carty, Nikisha, et al.
Publicado: (2015)

Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice
por: Li, Si Han, et al.
Publicado: (2022)

Small Molecule Pytren-4QMn Metal Complex Slows down Huntington’s Disease Progression in Male zQ175 Transgenic Mice
por: Merino, Marián, et al.
Publicado: (2023)

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease
por: Menalled, Liliana B., et al.
Publicado: (2014)

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2019)

Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD
por: Curtin, Paul C. P., et al.
Publicado: (2016)

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches
por: Smith, Edward J, et al.
Publicado: (2023)

A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington’s disease
por: Oakeshott, Stephen, et al.
Publicado: (2012)

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum
por: Pinchaud, Katleen, et al.
Publicado: (2023)

Personalized Metabolic Profile by Synergic Use of NMR and HRMS
por: Petrella, Greta, et al.
Publicado: (2021)

Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay
por: Papadopoulou, Aikaterini S., et al.
Publicado: (2019)

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease
por: Cutler, Tamara S., et al.
Publicado: (2017)

Global Rhes knockout in the Q175 Huntington’s disease mouse model
por: Heikkinen, Taneli, et al.
Publicado: (2021)

Search for t to Zq
por: CMS Collaboration
Publicado: (2012)

Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington’s Disease
por: Tanimura, Asami, et al.
Publicado: (2016)

Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice
por: Deng, Yunping, et al.
Publicado: (2020)

$t\overline{t}$+X and t+X production in CMS: $t\overline{t}$Z, $t\overline{t}$Z, $t\overline{t}$W, $t\overline{t}\gamma$, tZq, $t\gamma q$ in CMS
por: Palencia Cortezon, Jose Enrique
Publicado: (2019)

$t \bar t$+X and t+X production in CMS: $t \bar t$Z, $t \bar t$Z, $t \bar t$W, $t \bar t \gamma$, tZq,t$\gamma$q in CMS
por: Palencia Cortezon, Jose Enrique
Publicado: (2021)

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum
por: Iuliano, Maria, et al.
Publicado: (2021)

The Onset and Progression of Hippocampal Synaptic Plasticity Deficits in the Q175FDN Mouse Model of Huntington Disease
por: Quirion, Jade G., et al.
Publicado: (2019)

Impaired Performance of the Q175 Mouse Model of Huntington’s Disease in the Touch Screen Paired Associates Learning Task
por: Piiponniemi, Tuukka O., et al.
Publicado: (2018)

Studies on the Q175 Knock-in Model of Huntington’s Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory Dysfunction
por: Ferris, Craig F., et al.
Publicado: (2014)

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease
por: Wang, Huei-Bin, et al.
Publicado: (2018)

t$\bar{\mbox t}$+X and t+X production in CMS: t$\bar{\mbox{t}}$Z, t$\bar{\mbox{t}}$Z, t$\bar{\mbox{t}}$W, t$\bar{\mbox{t}}\gamma$, tZq, t$\gamma$q in CMS
por: Palencia Cortezon, Jose Enrique
Publicado: (2020)

The Q175 Mouse Model of Huntington’s Disease Shows Gene Dosage- and Age-Related Decline in Circadian Rhythms of Activity and Sleep
por: Loh, Dawn H., et al.
Publicado: (2013)

Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease
por: Whittaker, Daniel S., et al.
Publicado: (2017)

175. Evaluation of Optimal Urinalysis Criteria for Conditional Urine Culturing
por: Li, Cecilia, et al.
Publicado: (2022)

Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice
por: Li, Si Han, et al.
Publicado: (2023)

Rare top quark production at the LHC: t$\bar{\text{t}}$Z, t$\bar{\text{t}}$W, t$\bar{\text{t}}\gamma$, tZq, t$\gamma$q, and t$\bar{\text{t}}$t$\bar{\text{t}}$
por: Knolle, Joscha
Publicado: (2019)

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175(+/-) mouse model of Huntington’s Disease
por: Goodliffe, Joseph W., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_395g3e07lat8a9ole8hf51u31b