Cargando…
ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy
Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-reperfusion injury in the heart and several degenerative diseases, including muscular dystrophy (MD). MD is a family of genetic disorders characterized by progressive muscle necrosis and premature death. It has been...
Autores principales: | Bround, Michael J., Havens, Julian R., York, Allen J., Sargent, Michelle A., Karch, Jason, Molkentin, Jeffery D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456852/ https://www.ncbi.nlm.nih.gov/pubmed/37624892 http://dx.doi.org/10.1126/sciadv.adi2767 |
Ejemplares similares
-
Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy
por: Burr, A R, et al.
Publicado: (2015) -
Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death
por: Karch, Jason, et al.
Publicado: (2015) -
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy
por: Laurila, Pirkka-Pekka, et al.
Publicado: (2022) -
Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD
por: Karch, Jason, et al.
Publicado: (2019) -
Optogenetic modeling of human neuromuscular circuits in Duchenne
muscular dystrophy with CRISPR and pharmacological corrections
por: Paredes-Redondo, Amaia, et al.
Publicado: (2021)