Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice

Long-term ligand activation of PPARα in mice causes hepatocarcinogenesis through a mechanism that requires functional PPARα. However, hepatocarcinogenesis is diminished in both Ppara-null and PPARA-humanized mice, yet both lines develop age-related liver cancer independently of treatment with a PPAR...

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Detalles Bibliográficos
Autores principales: Zhu, Xiaoyang, Liu, Qing, Patterson, Andrew D., Sharma, Arun K., Amin, Shantu G., Cohen, Samuel M., Gonzalez, Frank J., Peters, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456914/
https://www.ncbi.nlm.nih.gov/pubmed/37623879
http://dx.doi.org/10.3390/metabo13080936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456914/
https://www.ncbi.nlm.nih.gov/pubmed/37623879
http://dx.doi.org/10.3390/metabo13080936

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