Combinatorial gene therapy for epilepsy: Gene sequence positioning and AAV serotype influence expression and inhibitory effect on seizures

Gene therapy with AAV vectors carrying genes for neuropeptide Y and its receptor Y2 has been shown to inhibit seizures in multiple animal models of epilepsy. It is however unknown how the AAV serotype or the sequence order of these two transgenes in the expression cassette affects the actual parench...

Descripción completa

Detalles Bibliográficos
Autores principales: Melin, Esbjörn, Andersson, My, Gøtzsche, Casper R., Wickham, Jenny, Huang, Yuzhe, Szczygiel, Julia Alicja, Boender, Arnie, Christiansen, Søren H., Pinborg, Lars, Woldbye, David P. D., Kokaia, Merab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457185/
https://www.ncbi.nlm.nih.gov/pubmed/37029201
http://dx.doi.org/10.1038/s41434-023-00399-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457185/
https://www.ncbi.nlm.nih.gov/pubmed/37029201
http://dx.doi.org/10.1038/s41434-023-00399-w

Ejemplares similares