Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells

Isocitrate dehydrogenase (IDH) mutations are found in 20% of acute myeloid leukemia (AML) patients. However, only 30–40% of the patients respond to IDH inhibitors (IDHi). We aimed to identify a molecular vulnerability to tailor novel therapies for AML patients with IDH mutations. We characterized th...

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Detalles Bibliográficos
Autores principales: Palau, Anna, Segerberg, Filip, Lidschreiber, Michael, Lidschreiber, Katja, Naughton, Aonghus J., Needhamsen, Maria, Jung, Lisa Anna, Jagodic, Maja, Cramer, Patrick, Lehmann, Sören, Carlsten, Mattias, Lennartsson, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457197/
https://www.ncbi.nlm.nih.gov/pubmed/37495775
http://dx.doi.org/10.1038/s41375-023-01972-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457197/
https://www.ncbi.nlm.nih.gov/pubmed/37495775
http://dx.doi.org/10.1038/s41375-023-01972-3

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