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Axonal Transport Defect in Gigaxonin Deficiency Rescued by Tubastatin A
Giant axonal neuropathy (GAN) is a disease caused by a deficiency of gigaxonin, a mediator of the degradation of intermediate filament (IF) proteins. A lack of gigaxonin alters the turnover of IF proteins, provoking accumulation and disorganization of neurofilaments (NFs) in neurons, a hallmark of t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457258/ https://www.ncbi.nlm.nih.gov/pubmed/37268847 http://dx.doi.org/10.1007/s13311-023-01393-1 |