Propensity of selecting mutant parasites for the antimalarial drug cabamiquine

We report an analysis of the propensity of the antimalarial agent cabamiquine, a Plasmodium-specific eukaryotic elongation factor 2 inhibitor, to select for resistant Plasmodium falciparum parasites. Through in vitro studies of laboratory strains and clinical isolates, a humanized mouse model, and v...

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Detalles Bibliográficos
Autores principales: Stadler, Eva, Maiga, Mohamed, Friedrich, Lukas, Thathy, Vandana, Demarta-Gatsi, Claudia, Dara, Antoine, Sogore, Fanta, Striepen, Josefine, Oeuvray, Claude, Djimdé, Abdoulaye A., Lee, Marcus C. S., Dembélé, Laurent, Fidock, David A., Khoury, David S., Spangenberg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457284/
https://www.ncbi.nlm.nih.gov/pubmed/37626093
http://dx.doi.org/10.1038/s41467-023-40974-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457284/
https://www.ncbi.nlm.nih.gov/pubmed/37626093
http://dx.doi.org/10.1038/s41467-023-40974-8

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